業 績 一 覧 2025

原著

1. Takahashi M, Nakamura K, Chiyoda T, Okada C, Nohara S, Takamatsu R, Yanazume S, Kobayashi H, Nishihara H. Transcriptome concordance between borderline tumors and endometrioid carcinoma: An integrative genomic analysis. Cancer Med. 2025 Jan;14(2):e70601.
2. Kobayashi R, Matsuda S, Nakamura K, Kawakubo H, Ho K, Morimoto Y, Hisaoka K, Hoshi Y, Takeuchi M, Fukuda K, Okui J, Nishihara H, Kitagawa Y. Clinical value of preoperative circulating tumor DNA before surgery in patients with esophageal squamous cell carcinoma. Eur J Surg Oncol. 2025 May;51(5):109625.
3. Suzuki S, Akahane T, Tanimoto A, Higashi M, Kitazono I, Kirishima M, Nishigaki M, Ikeda T, Kanemitsu S, Nakazawa J, Akahane E, Nishihara H, Uozumi K, Yoshimitsu M, Ishitsuka K, Ueno SI. Comparison of actionable alterations in cancers with kinase fusion, mutation, and copy number alteration. PLoS One. 2025 Jan 23;20(1):e0305025.
4. Chikaishi Y, Matsuoka H, Sugihara E, Takeda M, Sumitomo M, Yamada S, Inaguma G, Omura Y, Cheong Y, Kobayashi Y, Nakauchi M, Hiro J, Masumori K, Otsuka K, Nishihara H, Suda K, Saya H, Takimoto T. Mutation analysis of TMB-high colorectal cancer: Insights into molecular pathways and clinical implications. Cancer Sci. 2025 Jan 16. Online ahead of print.
5. Nagase Y, Kodama M, Aimono E, Nakamura K, Takamatsu R, Abe K, Yoshimura T, Chiyoda T, Yamagami W, Nishihara H. CXCL9 and CXCL13 shape endometrial cancer immune-activated microenvironment via tertiary lymphoid structure formation. Cancer Sci. 2025 May;116(5):1193-1202.
6. So E, Hayashi H, Shimozaki K, Horie S, Kishimoto S, Chida A, Saito Y, Tsugaru K, Hirata K, Tanishima S, Nishihara H, Kanai T, Hamamoto Y. Clinical utility of comprehensive genomic profiling for advanced pancreatic cancer: insights from real-world data analysis. Int J Clin Oncol. 2025 Feb 17. Online ahead of print.
7. Nakamura K, Masuda K, Seki T, Kitago M, Kosaka T, Goto Y, Yamada M, Misu K, Ono I, Kobayashi Y, Yamagami W. Potential new tumors associated with hereditary breast and ovarian cancer (HBOC) Keio J Med. 2025 Mar 12. Online ahead of print.
8. Kobayashi Y, Suzuki Y, Seishima R, Chikaishi Y, Matsuoka H, Nakamura K, Shigeta K, Okabayashi K, Hiro J, Otsuka K, Uyama I, Saya H, Nishihara H, Suda K, Kitagawa Y. Utility of comprehensive genomic profiling combined with machine learning for prognostic stratification in stage II/III colorectal cancer after adjuvant chemotherapy. Int J Clin Oncol. 2025 May;30(5):926-934.
9. Masuda K, Kobayashi Y, Seki T, Yoshihama T, Nakamura K, Goto Y, Yamada M, Nagayama A, Uchida S, Ono I, Misu K, Yokota M, Yamagami W. Current situation and future directions of risk-reducing salpingo-oophorectomy. Keio J Med. 2025 Mar 22. Online ahead of print.
10. Seki T, Kobayashi Y, Masuda K, Nakamura K, Yamada M, Goto Y, Misu K, Ono I, Nagayama A, Hayashida T, Kitagawa Y. Exploring breast cancer risk management in HBOC patients: Image surveillance versus risk-reducing surgery. Keio J Med. 2025 Apr 2. Online ahead of print.
11. Kato Y, Seishima R, Hattori K, Kato H, Ishida H, Shigeta K, Okabayashi K, Sugihara E, Takimoto T, Nakamura K, Nishihara H, Saya H, Kitagawa Y. Significance of homologous recombinant deficiency as a biomarker for drug sensitivity in colorectal cancer. Br J Cancer. 2025 Apr;132(6):533-542
12. Tanaka K, Mochizuki T, Baba S, Kawai S, Nakano K, Tachibana T, Uchimura K, Kato A, Miyayama T, Yamaguchi T, Nishihara H, Terao K, Kato Y. Robust and reproducible human intestinal organoid-derived monolayer model for analyzing drug absorption. Sci Rep. 2025 Apr 3;15(1):11403
13. Arai M, Tanaka N, Takamatsu K, Murakami T, Mikami S, Imamura T, Nakamura K, Nishihara H, Oya M. Prognostic impact and landscape of cellular CXCR5 chemokine receptor expression in clear-cell renal cell carcinoma. Cancer Immunol Immunother. 2025 Apr 10;74(5):166.
14. Abe K, Kitago M, Kobayashi Y, Masuda K, Seki T, Yamada M, Goto Y, Ono I, Misu K, Nakamura K, Kitagawa Y. Pancreatic Cancer in Hereditary Breast and Ovarian Cancer Syndrome: Is Early Detection Possible? Keio J Med. 2025 Apr 19. Online ahead of print
15. Yoshimura T, Nakamura K, Chiyoda T, Takamatsu R, Kawano R, Aimono E, Kawaida M, Sakai K, Masugi Y, Nishihara H, Yamagami W. Next-generation sequencing outperforms Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) in endometrial cancer molecular classification. BJC Rep. 2025 May 20;3(1):37.
16. Imaeda K, Tamura T, Nagai S, Sugihara E, Yamasaki J, Otsuki Y, Nakamura K, Takeda T, Nakamura K, Nogami Y, Tsuji K, Chiyoda T, Kisu I, Kobayashi Y, Banno K, Yamaguchi R, Sakurada K, Saya H, Aoki D, Ahmed AA, Nagano O, Masuda K, Yamagami W. LCN2-mediated ferroptosis resistance in tissue homeostasis and early-stage tumorigenesis of the fallopian tube epithelium. iScience. 2025 May 13;28(6):112654.
17. Takamatsu R, Nakamura K, Chiyoda T, Tsuji K, Kawano R, Yoshimi N, Yamagami W, Nishihara H. Advancing precision oncology: Whole-exome sequencing in endometrial cancer liquid-based cytology. Arch Pathol Lab Med. 2025 Jun 1;149(6):561-567.
18. Kobayashi Y, Masuda K, Seki T, Kosaka T, Kitago M, Ono I, Misu K, Ueki A, Yoshihama T, Nagayama A, Yasumizu Y, Goto Y, Nakamura K, Yamada M, Yokota M, Uchida S, Takeuchi M, Funakoshi T, Yamagami W. The Keio HBOC Center: A Model of Hereditary Breast and Ovarian Cancer Management. Keio J Med. 2025 Jun 20. Online ahead of print.
19. Fukushima T, Nakamura K, Terai H, Ohgino K, Kawano R, Ishikawa M, Emoto K, Takaoka H, Saito A, Ito F, Nukaga S, Ikemura S, Kawada I, Masuda K, Yasuda H, Okita H, Asakura K, Soejima K, Kosaki K, Nishihara H, Fukunaga K. Clinical sequence revealed the prevalence and biological significance of somatic pathogenic variants in thoracic cancer: Implications for germline status. Clin Lung Cancer. 2025 Jul 26(5):407-419.
20. Hsu CY, Yanagi T, Miyamoto K, Otsuguro S, Maenaka K, Nishihara H, Nakamura H, Takahashi K, Ujiie H. An FDA-approved drug library screening identifies proteasome inhibitors as selective cytotoxic agents for angiosarcoma cells. Br J Cancer. 2025 Jul;133(1):3-13.
21. Kubota A, Bandoh N, Goto T, Kono M, Sato R, Suzuki S, Sakaue S, Takeda R, Hayashi S, Hayashi M, Araki D, Baba S, Kato Y, Takahara M, Nishihara H, Kamada H. A retrospective study of laryngeal squamous cell carcinoma and the significance of the PIK3CA mutation for survival. Mol Clin Oncol. 2025 Jul 17;23(4):87.
22. Miyamoto K, Yanagi T, Maeda T, Kitamura S, Nishihara H, Iwamoto R, Takahashi K, Ujiie H. Eribulin inhibits tumor growth of two novel patient-derived xenograft models of Merkel cell carcinoma. J Dermatol Sci. 2025 Aug;119(2):82-89.
23. Takaoka H, Terai H, Nakamura K, Mizuno T, Kawano R, Emoto K, Kurebayashi Y, Takada N, Hamabe K, Horie K, Ogata A, Kinoshita K, Shigematsu L, Ito F, Okada M, Fukushima T, Nukaga S, Tani T, Ohgino K, Kaseda K, Ikemura S, Yasuda H, Asakura K, Okita H, Nishihara H, Fukunaga K. Clinical application of in-house comprehensive genomic profiling for thoracic cancer: insights from a Japanese hospital. Cancer Sci. 2025 Aug 4. Online ahead of print.

症例報告

1. Murata Y, Kosaka T, Nakamura K, Baba Y, Arai E, Yasumizu Y, Matsumoto K, Nishihara H, Oya M. A case of testicular dysgenesis syndrome with squamous cell carcinoma of the prostate harboring a CDK12 mutation. IJU Case Rep. 2025 Jan 2;8(2):125-128.
2. Ito K, Nakamura K, Kajihara T, Shinozaki Y, Imura J, Sakuma H. Coexistence of complete intestinal tract, prostatic tissue, prostatic urethra and bladder structure in ovarian mature cystic teratoma: a case report. Med Mol Morphol. 2025 Mar;58(1)91.
3. So E, Ishida N, Chida A, Horie S, Kishimoto S, Tsugaru K, Hayashi H, Koda Y, Ozaki M, Okita H, Kanai T, Hirata K. A rare case of ALK-positive histiocytosis with neurological involvement in a 70-year-old woman successfully managed with partial resection and alectinib. Int Cancer Conf J. 2025 Jun 3;14(3):327-334.
4. Fukunaga N, Terai H, Nomura R, Kurebayashi Y, Nakamura K, Kawano R, Shigeta K, Okabayashi K, Kinoshita K, Ogata A, Shigematsu L, Ito F, Takaoka H, Fukushima T, Nukaga S, Ohgino K, Yasuda H, Nishihara H, Kitagawa Y, Fukunaga K. Acquisition of FGFR1 and NSD3 amplifications during the transformation of EGFR-mutated lung adenocarcinoma into squamous cell carcinoma: a case report. JTO Clin Res Rep. 2025 Jun 13;6(9):100862.
5. Koyanagi A, Kakumoto A, Kuroda H, Baba S, Koketsu M, Harada O, Kato Y, Nishihara H, Kawami H. A Case of false-negative results in the one-step nucleic acid amplification assay for sentinel lymph node metastasis in breast cancer with low cytokeratin 19 expression. Case Rep Oncol. 2025 Jul 2;18(1):1074-1080.